Nonalcoholic fatty liver disease and the PNPLA3 gene.
نویسندگان
چکیده
Nonalcoholic fatty liver disease, a potentially fatal obesity-related condition, affects more than 70 million people in the United States. Nurses are well-positioned to impact this genetically influenced disease by is increasing awareness, providing patient education, and advocating for affected persons.
منابع مشابه
PNPLA3-associated steatohepatitis: toward a gene-based classification of fatty liver disease.
Nonalcoholic fatty liver disease is one of the most common hepatic disorders worldwide. Given the high-calorie nutrition of children and adults, nonalcoholic fatty liver disease (NAFLD) is expected to become a major cause of cirrhosis and eventually liver transplantation. Familial clustering and ethnic differences indicate that genetic factors contribute to NAFLD. Recently, the common variant p...
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متن کاملAssociation of rs738409 Polymorphism in the PNPLA3 Gene with Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and has an estimated incidence of 20%–30% in the general population and 67%–75% in the obese population. Genetic predisposition can play an important role in development of this disease. Nonsynonymous coding SNP rs738409 C/G (I148Met) in the PNPLA3 gene has been found to be associated with the presence of...
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عنوان ژورنال:
- Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses
دوره 23 2 شماره
صفحات -
تاریخ انتشار 2014